Indoleamine 2,3-dioxygenase and tumor-induced tolerance
نویسندگان
چکیده
منابع مشابه
Indoleamine 2,3-dioxygenase and tumor-induced tolerance.
Tumors arise from normal cells of the body through genetic mutation. Although such genetic mutation often leads to the expression of abnormal antigens, the immune system fails to respond effectively to these antigens; that is, it is tolerant of these antigens. This acquired state of tolerance must be overcome for cancer immunotherapy to succeed. Indoleamine 2,3-dioxygenase (IDO) is one molecula...
متن کاملIndoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy
Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN- γ is the main inducer of this enzyme. IDO acts as an important defense mechanism of innate immunity against pathogens. It also has tumor suppressive activity and prolong...
متن کاملIndoleamine 2,3-dioxygenase (ido) and Immune Tolerance
The IDO facilitates immune tolerance and is one of the main actors involved in the inhibition of cell proliferation, including activated T cells. IDO induces production of reactive oxygen species (ROS) and nitric oxide (NO) radicals. Several pathways involved in the regulation of immune response are regulated by redox mechanisms. Reactive oxygen and nitrogen species (ROSRNS) and other redox act...
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Over the past decades, Salmonella has been proven capable of inhibiting tumor growth. It can specifically target tumors and due to its facultative anaerobic property, can be more penetrative than other drug therapies. However, the molecular mechanism by which Salmonella inhibits tumor growth is still incompletely known. The antitumor therapeutic effect mediated by Salmonella is associated with ...
متن کاملindoleamine 2,3-dioxygenase and immunological tolerance during pregnancy
indoleamine 2,3-dioxygenase (ido), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. ifn- γ is the main inducer of this enzyme. ido acts as an important defense mechanism of innate immunity against pathogens. it also has tumor suppressive activity and prolong...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2007
ISSN: 0021-9738
DOI: 10.1172/jci31178